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PROGRAM

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PROGRAM
The 30th Annual Meeting of the Surgical Infection Society

Las Vegas, Nevada
April 17th – 20th, 2010

Accreditation Statement
This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education through the joint sponsorship of the American College of Surgeons and the Surgical Infection Society. The American College Surgeons is accredited by the ACCME to provide continuing medical education for physicians.

AMA PRA Category 1 Credits™
The American College of Surgeons designates this educational activity for a maximum of 19 AMA PRA Category 1 Credits™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

AMERICAN COLLEGE OF SURGEONS, DIVISION OF EDUCATION

SURGICAL INFECTION SOCIETY
THIRTIETH ANNUAL MEETING
Las Vegas, Nevada
APRIL 17-20, 2010
Saturday, April 17, 2010
11:00 - 12:00 Committee Meetings
   Informatics Desert
   Fellowship and Awards
   Scientific Studies		 Willow Foyer
Acacia Foyer
Ballroom Foyer
12:00 - 13:00 Council Luncheon Mesquite 2
13:00 - 17:00 Council Meeting Mesquite 1
17:00 - 18:00 Nominating Committee Mesquite 1
19:00 - 21:30 President’s Dinner (By invitation) Mesquite 1 - 2
 
Sunday, April 18, 2010
06:30 - 07:45 SUNRISE SYMPOSIUM I
IDSA Guidelines for Antibiotic Stewardship: Bad Bugs, No Drugs, ESKAPE
Moderator: TBD		 Ballroom 3 - 4
08:00 - 12:00 Surgical Infections Symposium: Annual Update
Moderator: Robert G. Sawyer, MD		 Ballroom 1 - 2
08:00 - 08:05 Welcome
   Robert G. Sawyer, MD
08:05 - 08:30 What is the Best Strategy in Recurrent or Persistent C. difficile Infection?
   Christine S. Cocanour, MD
08:30 - 09:55 Prevention of Hospital-Acquired Infections by Selective Digestive Decontamination
   R. Lawrence Reed, MD
09:55 - 09:20 What’s New in Diverticulitis?
   Gregory J. Beilman, MD
09:20 - 09:45 ECMO and Acute Lung Injury in Adults: Is There an Indication?
   Kristen Sihler, MD
09:45 - 10:00 Discussion
10:00 - 10:15 BREAK
10:15 - 10:40 Skin and Soft Tissue Infections - The New SIS Guidelines
   Addison K. May, MD
10:40 - 11:05 New Therapies in Treatment of Necrotizing Soft Tissue Infections
   Matthew R. Rosengart, MD
11:05 - 11:30 ChloraPrep and SSI Prevention: Clinical Trial Results
   Kamal M. F. Itani, MD
11:30 - 11:45 Discussion
11:45 - 12:00 Closing Remarks
12:00 - 13:30 LUNCHEON SYMPOSIUM I
A Mechanistic Approach to Reducing the Risk Factors of Surgical Site Infections
Moderator: E. Patchen Dellinger, M.D.		 Ballroom 3 - 4
Evidence-Based Role of the SCIP Initiative to Improve Surgical Outcomes.
   Robert G. Sawyer, MD

Reducing the Risk of SSI: Is there a Role for Innovative Technology to Improve Patient Outcomes?
   Charles E. Edmiston Jr., PhD
13:30 - 16:00 PLENARY SESSION I
The Art and Science of Surgical Infections (Papers 1 - 8)
Moderators: Lena M. Napolitano, MD and Henri R. Ford, MD, MHA		 Ballroom 1 - 2
1. MAINTENANCE OF THE GUT EPITHELIAL BARRIER VIA VAGAL NERVE STIMULATION PROTECTS AGAINST SECONDARY PULMONARY INJURY AFTER THERMAL INJURY
Michael J. Krzyzaniak, MD, Carrie Y. Peterson, MD, William H. Loomis, BS, James G Putnam, BS, Vince Kennedy, Vishal Bansal, MD, Brian Eliceri, PhD, Andrew N. Baird PhD, Raul Coimbra MD, PhD – University of California, San Diego
Discussant: Basil A. Pruitt Jr., MD
2. DELAY OF ELECTIVE SURGERY FOR HIGH VOLUME PROCEDURES: THE IMPACT ON INFECTIOUS COMPLICATIONS
Todd R. Vogel, MD, MPH, Viktor Y. Dombrovskiy MD, MPH, PhD, Stephen F. Lowry, MD, MBA – University of Medicine and Dentistry of New Jersey - Robert Wood Johnson Medical School
Discussant: E. Patchen Dellinger, MD
3. THE ROLE OF DENDRITIC CELLS IN ENTEROBACTER SAKAZAKII-INDUCED DISRUPTION OF THE EPITHELIAL CELL BARRIER: IMPLICATIONS FOR THE PATHOGENESIS OF NEC
Claudia N. Emami, MD, Rahul Mittal, PhD, Prasdarao V. Nemani, PhD, Henri R. Ford, MD, MHA - Children’s Hospital Los Angeles, University of Southern California
Discussant: William G. Cioffi, MD
4. URINARY TRACT INFECTIONS SIGNIFICANTLY WORSEN OUTCOMES IN TRAUMA PATIENTS; AN ANALYSIS OF 8,841 PATIENTS
Sean F. Monaghan, MD, Daithi S. Heffernan, MD, Rajan K Thakkar, MD, Steven E. Reinert, Jason T. Machan, PhD, Shea Gregg, MD, Matthew S. Kozloff, MD, Michael D. Connolly, MD, Charles A. Adams, MD, William G Cioffi, MD - Brown University, Rhode Island Hospital
Discussant: John C. Marshall, MD
5. TLR4 INDUCED AUTOPHAGY INCREASES BACTERIAL INTERNALIZATION BY ENTEROCYTES
Matthew D. Neal, MD, Chhinder P. Sodhi, PhD, Ward M. Richardson MD, Amin Afrazi, BS, Richard Siggers, PhD, David J. Hackam, MD, PhD - Division of Pediatric Surgery, Department of Surgery, University of Pittsburgh Medical Center
Discussant: Henri R. Ford, MD
6. PROPHYLACTIC ANTIBIOTIC DAYS AS A PREDICTOR OF SENSITIVITY PATTERNS IN ACINETOBACTER PNEUMONIA
Parth B. Amin, MD, Louis J. Magnotti, MD, Peter E. Fischer, MD, Martin A. Croce, MD, Timothy C. Fabian, MD - Presley Trauma Center, University of Tennessee, Memphis
Discussant: Lena M. Napolitano MD
7. EVIDENCE THAT LETHAL GUT-DERIVED SEPSIS DUE TO CANDIDA ALBICANS IN MICE IS DEPENDENT ON THE LOCAL CONCENTRATION OF PHOSPHATE
Kathleen S. Romanowski, MD, Alex Zaborin, PhD, Vesta Valuckaite, MD, Trissa A. Babrowski, MD, David Fink, MD, Irina Morozova, MS, Donald C Liu, MD, PhD, Jeffery B. Matthews, MD, Olga Zaborina PhD, John C. Alverdy, MD - University of Chicago
Discussant: Pamela A. Lipsett, MD
8. THE PRESENCE OF SPECIFIC BACTERIAL ORGANISMS PREDICTS MORTALITY IN PATIENTS WITH INTRA-ABDOMINAL INFECTIONS
William H. Leukhardt, MD, Jeffrey W. Carter, MD, Manjunath Haridas, MD, Tazo S. Inui, MD, Mark A. Malangoni, MD, Jeffrey A. Claridge, MD, MS - MetroHealth Medical Center
Discussant: Roger W. Yurt, MD
16:00 - 16:15 FELLOWSHIP AWARDS PRESENTATIONS
Presiding Officer: Craig Coopersmith, MD		 Ballroom 1 - 2
16:15 - 17:00 WILLIAM A. ALTEMEIER MEMORIAL LECTURE

Epigenetic Regulation of the Immune Cell Phenotype during Severe Sepsis
Steven L. Kunkel, PhD
Professor of Pathology
Senior Associate Dean for Research
Endowed Professor of Pathology Research and
Co-Director, Division of Sponsored Programs
University of Michigan School of Medicine

Introduction by Lena M. Napolitano, MD
University of Michigan

 Ballroom 1 - 2
17:30 - 18:15 SURGICAL INFECTIONS EDITORIAL BOARD RECEPTION
By Invitation		 Desert Willow
18:15 - 19:00 SURGICAL INFECTION SOCIETY FOUNDATION MEETING Cottonwood
18:00 - 20:00 WELCOME RECEPTION Poolside
20:00 - 22:00 SURGICAL INFECTION SOCIETY FOUNDATION DINNER
By Invitation		 Aureole
Mandalay Bay
 
Monday, April 19, 2010
06:30 - 07:45 AM SUNRISE SYMPOSIUM II
A High Stakes Game: Beating the Odds against MRSA in Surgical Infections
Moderator: Lena Napolitano, MD		 Ballroom 3 - 4
Epidemiology and Risk Factors
   Donald E. Fry, MD
Case Presentations
   Lena M. Napolitano, MD
New Options for Therapy
   Philip S. Barie, MD, MBA
08:00 - 10:30 AM PARALLEL SESSION I
Fundamental Mechanisms of Surgical Infection (Papers 9 – 16)
Moderators: Stephen F. Lowry, MD, MBA and William G. Cheadle, MD		 Acacia 1
9. VAGAL NERVE STIMULATION MODULES INTESTINAL TIGHT JUNCTION PROTEIN EXPRESSION THROUGH THE ACTIVATION OF ENTERIC GLIA CELLS
Todd W. Costantini, MD, Carrie Y. Peterson, MD, James G. Putnam, BS, William H. Loomis, BS, Seok Yong Ryu, MD, PhD, Vishal Bansal, MD, Raul Coimbra, MD, PhD - University of California, San Diego
Discussant: John C. Alverdy, MD
10. INTESTINAL PHOSPHATE DEPLETION DEVELOPS DURING HUMAN CRITICAL ILLNESS AND ACTIVATES THE VIRULENCE OF KEY COLONIZING PATHOGENS ASSOCIATED WITH GUT-DERIVED SEPSIS
Alexander V. Zaborin, PhD, Kathleen Romanowski, MD, Irina Morozova, MS, Cindy Bethel, MT, (ASCP), Trissa Babrowski, MD, Andrea Olivas, MD, David Fink, MD, Karen Frank, MD, PhD, Donald Liu MD, PhD, Olga Zaborina, PhD, John C. Alverdy, MD - University of Chicago
Discussant: Jared Huston, MD
11. TIR DOMAIN VARIANTS OF MAL/TIRAP RESULT IN ALTERED TLR4 SIGNALING
Kaysie L. Banton, MD, Karen A. McCulloch, BS, Karen R. Wasiluk, PhD - University of Minnesota
Discussant: Edwin A. Deitch, MD
12. LATE POST-TRAUMATIC IMMUNE DYSFUNCTION: THE ROLE OF TLR2 AND TLR4 SIGNALING
Sophie S Darwiche, MD, Xiangcai Ruan, MD, Melanie Scott, MD, PhD, Rosemary Hoffman, PhD, Hans - Christoph Pape, MD, Timothy R. Billiar, MD - University of Pittsburgh
Discussant: Saman Arbabi, MD
13. MKP-1 PROMOTES TOLERANCE TO TLR LIGANDS IN ENTEROCYTES
Jin Wang, MS, Anatoly V. Grishin, PhD, Henri R. Ford, MD, MHA - Children’s Hospital Los Angeles
Discussant: Marc Jeschke, MD
14. PLATELET CD154 MEDIATES REMOTE TISSUE INJURY FOLLOWING MESENTERIC ISCHEMIA AND REPERFUSION
Peter H. Lapchak, MSc, PhD, Poonam Rani, MSc, Lakshmi Kannan ,PhD, Jurandir J. Dalle Lucca, MD, George C. Tsokos, MD - Beth Israel Deaconess Medical Center and Harvard Medical School
Discussant: Stephen F. Lowry, MD, MBA
15. BETA BLOCKADE PREVENTS HEMATOPOIETIC PROGENITOR CELL SUPPRESSION FOLLOWING HEMORRHAGIC SHOCK
Ihab O. Elhassan, MD, Edward J. Hannoush, MD, Walter D. Alzate, BSc, MSc, Ziad C. Sifri, MD, David H. Livingston, MD, Alicia M. Mohr, MD - University of Medicine and Dentistry of New Jersey - New Jersey Medical School
Discussant: Alfred Ayala, PhD
16. P-GLYCOPROTEIN IS REQUIRED FOR BREAST MILK-INDUCED PROTECTION FROM NECROTIZING ENTEROCOLITIS IN A NEONATAL MOUSE MODEL
Shannon L. Castle, MD, Jin Wang, MS, Monica Williams, BS, Anatoly V. Grishin, PhD, Jeffrey S. Upperman, MD*, Henri R. Ford, MD, MHA - Childrens’ ’Hospital Los Angeles, University of Southern California
Discussant: Evan P. Nadler, MD
08:00 - 10:30 PARALLEL SESSION II
Clinical Investigations in Surgical Infection (Papers 17 - 24)
Moderators: Philip S. Barie, MD, MBA and John C. Marshall, MD		 Ballroom 1 - 2
17. A CONCISE INSTRUMENT FOR SEPSIS SCREENING IN GENERAL SURGERY PATIENTS
Laura J. Moore, MD, Stephen L. Jones, MD, Krista L. Turner, MD, Samual R. Todd, MD, Shirley Kung, RN, Frank Stokes RN, ACNP, Craig W. Johnson, PhD, Gloria L. Beriones, RN, Frederick A. Moore, MD - The Methodist Hospital, Houston
Discussant: Samir Fahkry, MD
18. ROUTE OF FEEDING DIFFERENTIALLY INFLUENCES MONOCYTE GENE EXPRESSION
Beth-Ann Shanker, MD, Chun Choi, MD, Susette M.Coyle, RN, MSN, Marie A. Macor, RN, John L. Nosher, MD, Steve E. Calvano, PhD, Stephen F. Lowry, MD - University of Medicine and Dentistry of New Jersey - Robert Wood Johnson Medical School
Discussant: Martin A. Croce, MD
19. PREDICTIVE VALUE OF IL-8 FOR SEPSIS AND SEVERE INFECTIONS AFTER BURN INJURY - A CLINICAL INVESTIGATION.
Robert Kraft, MD, David N. Herndon, MD, Juquan Song, MD, Gabriela A. Kulp, MS, Marc G. Jeschke, MD, PhD - University of Texas Medical Branch, Galveston
Discussant: Henri R. Ford, MD, MPA
20. INTERVAL APPENDECTOMY AFTER NON-OPERATIVE MANAGEMENT OF ACUTE APPENDICITIS AT A CANCER CENTER
Tiffany T. Fancher, MD, Frederic M. Pieracci, MD, MPH, Soumitra Eachempati, MD, Laila Rashidi, MS, Garrett M Nash, MD, MPH - Memorial Sloan Kettering Hospital, New York
Discussant: Matthew Rosengart, MD, MPH
21. MASSIVE TRANSFUSION DOES NOT CAUSE INFECTIONS IN THE CRITICALLY ILL
William D. Dutton, MD, Chadi T. Abouassaly, MD, Bryan A. Cotton, MD, MPH, Addison K. May, MD, Oliver L. Gunter, MD - Vanderbilt University Medical Center
Discussant: Philip S. Barie, MD, MBA
22. CHRONOLOGICAL STUDY OF BACTERIAL FLORA IN CONTAMINATED WOUNDS
Shirin Towfigh, MD, Tatyan Clarke, MD, Ankur Gupta, MD, Diane M. Citron, MS - Cedars - Sinai Medical Center
Discussant: Kamal M. F. Itani, MD
23. CEFAZOLIN DOSING FOR SURGICAL PROPHYLAXIS IN MORBIDLY OBESE PATIENTS
Vanessa P. Ho, MD, David P. Nicolau, PharmD, Gregory F. Dakin, MD, Alfons Pomp, MD, Barrie S. Rich, MD, Christopher W. Towe, MD, Philip S. Barie, MD, MBA - Weill Cornell Medical College
Discussant: J. Wesley Alexander, MD
24. URETERAL STENT PLACEMENT IS A SIGNIFICANT RISK FACTOR FOR THE DEVELOPMENT OF BK VIREMIA AFTER RENAL TRANSPLANTATION
Leon Kushnir, MD, Karinn Chambers, MD, Michael H. Gallichio, MD, David J. Conti, MD - Albany Medical College of Union University
Discussant: Robert G. Sawyer, MD
10:30 – 11:00 BREAK - VISIT EXHIBITS Ballroom Foyer
11:00 - 12:00 PRESIDENTIAL ADDRESS
Answering the Call to Action: Response to the January 12, 2010 Haiti Earthquake
Henri R. Ford, MD, MHA
Vice President and Chief of Surgery
Children’s Hospital of Los Angeles
Professor and Vice-Chair for Clinical Affairs, Department of Surgery
Vice-Dean for Medical Education
Keck School of Medicine of the University of Southern California

Introduction by Lena M. Napolitano MD
University of Michigan

 Ballroom 1 - 2
12:00 - 13:30 LUNCHEON SYMPOSIUM II
Abdominal Wall Reconstruction: A Paradigm Shift in Managing Infection Risk
Faculty: Kamal M. F. Itani, MD, Parag Bhanot, MD, and Robert Martindale, MD
 		 Ballroom 3 - 4
13:30 – 16:00 PARALLEL SESSION III
Understanding the Host Response to Surgical Infection (Papers 25 - 32)
Moderators: James A. Lederer, PhD and Timothy R. Billiar, MD		 Acacia 1
25. PARENTERAL NUTRITION (PN) IMPAIRS LYMPHOTOXIN RECEPTOR (LTbR) SIGNALING VIA NF-kB
Jinggang Lan, PhD, Aaron F. Heneghan, PhD, Yoshifumi Sano, MD, Mark Jonker, MD, Jiro Omata, MD, Yang - Xin Fu, MD, PhD, Wentong Xu, MD, Joe Pierre, MA, Kenneth Kudsk, MD – University of Wiscinsin - Madison
Discussant: Paul Bankey, MD PhD
26. VARIABLE IGA PROTEASE ACTIVITY BY BACTERIAL PATHOGENS: EFFECT ON PMN INFLAMMATORY POTENTIAL
Lawrence N. Diebel, MD, David M. Liberati, MS - Wayne State University
Discussant: Ori D. Rotstein, MD
27. TREATMENT EFFECTS OF RECOMBINANT HUMAN SOLUBLE THROMBOMODULIN IN PATIENTS WITH SEVERE SEPSIS: PRELIMINARY HISTORICAL CONTROL STUDY
Kazuma Yamakawa, MD, Tomoyoshi Mohri, MD, Takeyuki Kiguchi, MD, Junichi Kitayama, MD, Hiroki Matsuda, MD, Yasushi Nakamori, MD, Satoshi Fujimi, MD. Sponsor: William Cheadle, MD - Osaka General Medical Center
Discussant: Michael A. West, MD, PhD
28. ILEAL FATTY ACID BINDING PROTEIN (I-FABP) A NOVEL BIOMARKER FOR ACUTE INTESTINAL ISCHEMIA AND RESULTANT LUNG INJURY
Rachel G. Khadaroo, MD, PhD, Spyridon Fortis, MD, Cathy Streutker, MD, MSc, Haibo Zhang, MD, PhD - University of Alberta
Discussant: Mark A. Wilson, MD, PhD
29. HUMAN MILK INDUCES DOSE- AND TIME- DEPENDENT P-GLYCOPROTEIN EXPRESSION IN HUMAN ENTEROCYTE CELL LINES
Ashanti L. Franklin, BA, Yigit Guner, MD, Monica Williams, BS, Jeffrey S. Upperman, MD, Anatoly Grishin, PhD, Henri R. Ford, MD, MHA – Children’s Hospital Los Angeles, University of Southern California
Discussant: Timothy R. Billiar, MD
30. IMMUNE-RELATED BIOMARKERS AND THE DEVELOPMENT OF NOSOCOMIAL INFECTION IN ICU PATIENTS
Chun W. Choi, MD, Beth - Ann Shanker, MD, MS, Susette M. Coyle, RN, Marie A. Macor, RN, Steve E. Calvano, PhD, Stephen F. Lowry, MD – University of Medicine and Dentistry of New Jersey - Robert Wood Johnson Medical School
Discussant: James A. Lederer, PhD
31. PEROXYNITRITE MEDIATES VASCULAR LEAKAGE VIA PROMOTING ANGIOPOEITIN-2 IN METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS-INDUCED SEPSIS
Perenlei Enkhbaatar, MD, PhD, Yong Zhu, MD, PhD, Sebastian Rehberg, MD, Yusuke Yamamoto, MD, PhD, Linda Sousse, BS, Lillian D. Traber, RN, David Herndon, MD, Daniel L. Traber, PhD - University of Texas Medical Branch, Galveston
Discussant: Philip Efron, MD
32. THE INTERFERON REGULATORY FACTOR-1 REGULATES THE BALANCE BETWEEN APOPTOSIS AND AUTOPHAGY IN ENDOTOXEMIA
Lemeng Zhang, Pinhua Pan, John Evankovich, Jon Cardinal, Timothy Billiar, MD, Allan Tsung, MD – University of Pittsburgh Medical Center
Discussant: Jared Huston, MD
13:30 – 16:00 PARALLEL SESSION IV
Outcomes Studies in Surgical Infection (Papers 33 - 40)
Moderators: Jörg Schröder, MD and Soumitra R. Eachempati, MD		 Ballroom 1 - 2
33. REPORT CARD ON SURGICAL CARE IMPROVEMENT PROJECT (SCIP): NNIS INFECTION DATA 2001 THROUGH 2006.
John Mihran Davis, MD, Yen - Hong Kuo, ScM, MS, Yen - Liang Kuo, MD, Nasim Ahmed, MD - Jersey Shore University Medical Center
Discussant: Donald E. Fry, MD
34. RECONSIDERATION FOR CULTURING VASCULAR CATHETERS FOR SUSPECTED CR-BSI IN THE ICU
Alexander Rose, MD, Jing Zhao, PharmD, Krista Wahby, PharmD, Bryan Dotson, PharmD, Steven Tennenberg, MD - Wayne State University School of Medicine
Discussant: Lewis Kaplan, MD
35. THE NORMALIZATION OF HYPERCORTISOLEMIA POST-BURN WITH KETOCONAZOLE DOES NOT ATTENUATE THE HYPERMETABOLIC CATABOLIC RESPONSE
Felicia N. Williams, MD, David N. Herndon, MD, David L. Chinkes PhD, Gabriela A. Kulp, MS, Arny Ferrando, PhD, Oscar E. Suman, PhD, Celeste Finnerty, PhD, Robert Kraft, MD, Ludwik K. Branski, MD, Ahmed M. Al - mousawi, MD, Mark G. Jeschke, MD, PhD – University of Texas Medical Branch - Galveston
Discussant: Lillian Kao, MD
36. EFFECT OF BODY MASS INDEX (BMI) ON CLINICAL RESPONSE TO TREATMENT FOR COMPLICATED INTRAABDOMINAL INFECTION (cIAI)
Nicholas Namias, MD, Darcy A. Hille, MS - University of Miami Miller School of Medicine
Discussant: Vincente H. Gracias, MD
37. WITHDRAWN
38. FAILURE TO NORMALIZE LYMPHOCYTE REDUCTION FOLLOWING TRAUMA IS ASSOCIATED WITH INCREASED MORTALITY, INDEPENDENT OF THE LEUKOCYTOSIS PATTERN.
Daithi S. Heffernan, MD, Sean F. Monaghan, MD, Rajan K. Thakkar, MD, Jason T. Machan, PhD, Alfred Ayala, PhD, William G. Cioffi, MD - Department of Surgery, Rhode Island Hospital, Brown University
Discussant: William Chien - Chen Chiu, MD
39. EMPIRIC ANTIBIOTICS PENDING BAL RESULTS IN PATIENTS WITHOUT PNEUMONIA SIGNIFICANTLY ALTERS THE FLORA BUT NOT THE RESISTANCE PROFILE IF A SUBSEQUENT PNEUMONIA DEVELOPS
Rajan K. Thakkar, MD, Sean F. Monaghan, MD, Daithi S. Heffernan, MD, Charles A. Adams, MD, Michael D. Connolly, MD, Shea Gregg, MD, Matthew S. Kozloff, MD, William G. Cioffi, MD - Department of Surgery, Rhode Island Hospital, Brown University
Discussant: Philip S. Barie, MD, MBA
40. LOCAL VARIATIONS IN EPIDEMIOLOGY, MICROBIOLOGY, AND OUTCOME OF NECROTIZING SOFT TISSUE INFECTIONS: A MULTI-CENTER STUDY.
Lillian S. Kao, MD, MPH, Debbie F. Lew, MPH, Samer N. Arab, MD, S. Rob Todd, MD, Matthew M. Carrick MD, Michael G. Corneille, MD, Samir S. Awad, MD, Kevin P. Lally, MD, MS - University of Texas Health Science Center at Houston
Discussant: Jose Diaz, MD
16:00 - 18:00 Poster Session (Posters 1 - 69)
Basic and Clinical Studies in Surgical Infection		 Acacia Foyer/Acacia 2
Moderators: (Posters 1 - 10) Hobart W. Harris, MD and Jared M. Huston, MD
(Posters 11 - 20) Marc G. Jeschke, MD, PhD and Fredric M. Pieracci, MD
(Posters 21 - 31) David Greenhalgh, MD and Charles Yowler, MD
(Posters 32 - 42) Alicia M. Mohr, MD and Samir S. Awad, MD
(Posters 43 - 53) Gary C. An, MD and Heather L. Evans, MD
(Posters 54 - 63) Nicole A. Stassen, MD and Saman Arbabi, MD
P1. A MULTICENTER, RANDOMIZED, CONTROLLED CLINICAL TRIAL COMPARING CIPROFLOXACIN WITH MEROPENEM FOR TREATMENT OF POSTOPERATIVE INFECTIONS, FINAL REPORT OF POSTOPERATIVE INFECTION TREATMENT STUDY GROUP OF JAPAN SOCIETY FOR SURGICAL INFECTION
Shinya Kusachi, MD, PhD, Yoshiki Takahashi, MD, PhD, Koumei Kato, MD, PhD, Shigeto Oda, MD, PhD, Hiromitsu Takeyama, MD, PhD, Keiji Mashita MD, PhD, Shinichi Kobayashi, PhD, Yoshinobu Sumiyama MD, PhD - Japan Society of Surgical Infection
P2. ANTIBIOTIC REGIMEN AND TIMING OF PROPHYLAXIS ARE IMPORTANT FACTORS FOR LIMITING SURGICAL SITE INFECTION (SSI) IN ELECTIVE ABDOMINAL COLORECTAL SURGERY (ECRS)
Vanessa P. Ho, MD, Philip S. Barie, MD, MBA, Sharon L. Stein, MD, Koiana Trencheva, MS, Jeffrey W. Milsom, MD, Sang W. Lee, MD, Toyooki Sonoda, MD - Weill Cornell Medical College
P3. MEASURING SPATIAL DIFFERENCES IN PSEUDOMONAS AERUGINOSA DISTRIBUTION AND VIRULENCE ACTIVATION RELATED TO INTESTINAL ISCHEMIA REPERFUSION INJURY
David Fink, MD, Kathleen Romanowski, MD, Trissa Babrowski, MD, Vesta Valuckaite, MD, Alex Zaborin, PhD, Valeriy Poroyko, PhD, Irina Morozova, MS, Olga Zaborina, PhD, John Alverdy, MD - University of Chicago
P4. THE INFLUENCE OF INOS ON THE AUTOPHAGIC RESPONSE IN SEPSIS
Evie H. Carchman, MD, Brian S. Zuckerbraun, MD – University of Pittsburgh Medical Center
P5. IS THE MORBIDITY OF SECONDARY PERITONITIS A RESULT OF THE PATHOGENS EXPRESSING ENHANCED VIRULENCE
Trissa A. Babrowski, MD, Kathleen Romanowski, MD, David Fink, MD, Donald Liu, MD, PhD, Olga Zaborina, PhD, John Alverdy, MD - University of Chicago
P6. PROTEIN KINASE C PLAYS A ROLE IN ENTEROBACTER SAKAZAKII INDUCED INTESTINAL EPITHELIUM PERMEABILITY
Quin Y. Liu, MD, Rahul Mittal, PhD, Anatoly Grishin, PhD, Henri R. Ford, MD, Nemani V. Prasadarao, PhD – Children’s Hospital Los Angeles
P7. COMPARISON OF ANTIMICROBIAL SUSCEPTIBILITY AND INCIDENCE OF EXTENDED-SPECTRUM BETA-LACTAMASE - PRODUCING ISOLATES IN MEDICAL INTENSIVE CARE UNITS VERSUS SURGICAL INTENSIVE CARE UNITS: RESULTS FROM SMART 2008 - 2009
Robert Badal, BS, Samuel Bouchillon, MD, Meredith Hackel, PhD, Aaron Johnson, BS - IHMA, Inc
P8. CEFTAROLINE ACTIVITY AGAINST CLINICAL ISOLATES OF STAPHYLOCOCCUS AUREUS, INCLUDING METHICILLIN-RESISTANT STRAINS (MRSA), FROM UNITED STATES (USA) HOSPITALS
Helio S. Sader, MD, PhD, Donald Biek, Ian Critchley, David J. Farrell, PhD, Ronald N. Jones, MD - JMI Laboratories
P9. PROPRANOLOL SUPPRESSES APOPTOSIS AND PRODUCTION OF INFLAMMATORY CYTOKINES IN LPS-STRESSED HUMAN MACROPHAGE - LIKE THP-1 CELLS
Kita Katsuhiro, PhD, Felicia Williams, MD, Rong Chu, Olga Obie, Gabreila Kulp, MS, David N. Herndon MD, Marc G. Jeschke, MD, PhD – University of Texas Medical Branch - Galveston
P10. DO BLOOD STREAM INFECTIONS AFFECT OUTCOME IN TRAUMA PATIENTS?
Ziad C Sifri MD, Alicia A Mohr MD, Helen S. Horng, PharmD, Robert Lavery, MS, David H. Livingston, MD – University of Medicine and Dentistry of New Jersey - New Jersey Medical School
P11. QUANTITATIVE WOUND CULTURES - AN IMPORTANT MONITORING FACTOR IN CLINICAL PRACTICE
Robert Kraft, MD, Ahmed A Al - Mousawi, MD, David N. Herndon, MD, Song Juquan, MD, Marc G. Jeschke, MD, PhD - University of Texas Medical Branch, Galveston
P12. IMPACT OF TIMING OF TRACHEOSTOMY IN THE INCIDENCE OF PNEUMONIA FOLLOWING SEVERE HEAD INJURY
Nasim Ahmed, MD, Yen - Hong Kuo, ScM, MS, Yen - Liang Kuo, MD, John M. Davis, MD - Jersey Shore University Medical Center
P13. CAN WE FIND BETTER MARKERS FOR IMMUNE AND PHYSIOLOGICAL DYSFUNCTION IN THE CRITICALLY ILL? THE CASE FOR PD-1
Sean F. Monaghan, MD, Rajan K. Thakkar, MD, Mai L. Tran, BS, Xin Huang, PhD, William G. Cioffi, MD, Alfred Ayala, PhD, Daithi S. Heffernan, MD, - Rhode Island Hospital/Alpert Medical School of Brown University
P14. TEMPORARY ABDOMINAL CLOSURE IN PATIENTS WITH SEVERE INTRAABDOMINAL INFECTION: A COHORT STUDY.
Elio Sanchez, MD, Oscar Heilbron, MD, Maria F. Jimenez, MD, Fabian Gil, MsC, Aura Rivera, MD, Nelson Nino MD, Juan Ayala, MD, Alvaro Sanchez, MD, MsC, Juan C. Puyana, MD - Pontificia Universidad Javeriana
P15. IS THERE A RELATIONSHIP BETWEEN ELEVATED VANCOMYCIN TROUGH CONCENTRATIONS (VT) AND INCREASED EFFICACY OR TOXICITY
Bruce H. Ackerman, PharmD, Kristen Phillips, Robert E. Guilday, MD, Mary L. Patton, MD, Linwood R. Haith Jr., MD - Crozer - Chester Medical Center
P16. PHYSIOLOGICAL LEUKOCYTOSIS IS NOT PHYSIOLOGIC FOLLOWING NON-TRAUMA SPLENECTOMY
Kathleen S. Romanowski, MD, Alaine Kamm, APN, Alex Bailey BS, Kevin K Roggin MD, Jeffery B Matthews MD, John C. Alverdy, MD - University of Chicago
P17. E-101 SOLUTION, A NOVEL ANTISEPTIC INTENDED FOR DIRECT APPLICATION WITHIN A SURGICAL WOUND TO PREVENT SURIGICAL SITE INFECTION: BLINDED, CONTROLLED PHASE 1 SKIN IRRITATION STUDY IN HEALTHY VOLUNTEERS
Peter O'Hanley PhD, MD, MPH, Christopher Beausoleil, CCRP, Kelly O'Hanley, MD, MPH, Steve Stephens - Exoxemis Inc.
P18. THE REDUCTION OF HEPATIC ALBUMIN EXPRESSION IS ASSOCIATED WITH ER STRESS DEACTIVATED EEF2 AFTER BURN INJURY
Juquan Song, MD, Robert Kraft MD, Xiaojun Zhang, MD, David N. Herndon, MD, Darren Boehning, PhD, Marc G. Jeschke, MD, PhD - Shriners Hospitals for Children and the University of Texas Medical Branch, Galveston
P19. INVOLVEMENT OF ENDOTOXIN IN THE MORTALITY OF MICE WITH GUT-DERIVED SEPSIS DUE TO METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS
Masashi Uramatsu, Tetsuya Matsumoto, Kazuhiro Tateda, Shuichi Miyazaki, Tetsuya Horino, Masaski Tanabe, Kazutoshi Shibuya, Junko Sato, Shinya Kusachi, Keizo Yamaguchi - The Third Department of Surgery, Toho University Ohashi Hospital, Japan
P20. ANTIMICROBIAL ACTIVITY AND SPECTRUM OF THE NOVEL CEPHALOSPORIN CEFTAROLINE TESTED AGAINST BACTERIAL ISOLATES CAUSING SKIN AND SKIN STRUCTURE INFECTIONS IN USA MEDICAL CENTERS.
David J. Farrell, PhD, Ian Critchley, Donald Biek , Ronald N. Jones MD, Helio S Sader MD, PhD - JMI Laboratories
P21. SEASONALITY OF PATHOGENS: A 7-YEAR STUDY OF CULTURE RESULTS FROM A SURGICAL ICU
Stefan Engstrom, Patrick R. Norris, Kenneth A. Debelak, Raymond L. Mernaugh, Sarah D. Valenti, Judith M. Jenkins, Michael B. Daly, Addison K. May, MD, Erik M. Boczko - Vanderbilt University
P22. ANTIBIOTICS PRIOR TO PEG PLACEMENT SIGNIFICANTLY REDUCES SURGICAL SITE INFECTIONS IN CRITICALLY INJURED TRAUMA PATIENTS
Ian R. Driscoll, MD, Gerard P. De Castro, MD, Grant V. Bochicchio, MD, MPH, Shijun Zhu, PhD, Sara M. Edeiken, Kelly Bochicchio, RN, MS, Obeid N. Ilahi, MD, Manjari Joshi, MD, Thomas M. Scalea, MD - Walter Reed Army Medical Center
P23. THE DEVELOPMENT OF RETROGRADE BACTERIAL EPIDIDYMITIS FOLLOWING VASECTOMY
Amani D. Politano, MD, Tony Mammen, MD, Raymond A. Costibile, MD, Jeffrey J. Lysiak, PhD, Terry T. Turner, PhD - University of Virginia (Sponsor: Robert G. Sawyer, MD)
P24. CONTEMPORARY PREDICTORS OF CONVERSION FROM LAPAROSCOPIC TO OPEN APPENDECTOMY
Patrick L. Wagner, MD, Soumitra R. Eachempati, MD, Lynn J. Hydo, RN, MBA, Frederic M. Pieracci, MD, MPH, Marie Bartholdi, Ben - Paul N. Umunna, Jian Shou, MD, Philip S. Barie, MD, MBA - NewYork - Presbyterian Hospital/Weill Cornell Medical Center
P25. ANTIBIOTIC USE AND SURGICAL MANAGEMENT IN 217 PATIENTS WITH MRSA SKIN AND SOFT TISSUE INFECTIONS
Peter K. Kim, MD, Dena G. Arumugam, BA, Stanley S. Cho, MPH, Stanislav Nosik, MD, Hugh Boothe, PhD - Jacobi Medical Center
P26. PREHOSPITAL INTUBATION FACTORS AND VENTILATOR ASSOCIATED PNEUMONIA IN TRAUMA PATIENTS
Heather L. Evans, MD, MS, Keir J. Warner, BS, Eileen M. Bulger, MD, Sam R. Sharar, MD, Ronald V. Maier, MD, Joseph Cuschieri, MD - Harborview Medical Center, University of Washington
P27. BLOOD TRANSFUSION INDUCES LATE CHANGES IN SPLEEN LEUKOCYTES.
Philip A. Efron, MD, Dina C. Nacionales, MD, Kindra Kelly - Scumpia, PhD, Alex G. Cuenca, MD, Matthew Delano, MD, PhD, Darwin N. Ang, MD, PhD, MPH, Lyle L. Moldawer, PhD - University of Florida
P28. MECHANISTIC COMPUTATIONAL REPRESENTATION OF PATHOGEN RESPONSE TO MICROENVIRONMENT CHANGES DURING HOST STRESS
John Seal, MD, John Alverdy, MD, Trissa Babrowski, MD, David Fink, MD, Kathleen Romanowski, MD, Olga Zaborina, PhD, Gary An, MD - University of Chicago
P29. EVALUATION OF THE APACHE II, SOFA, SIRS, & ISS SCORING SYSTEMS IN PREDICTING OUTCOME IN CRITICALLY ILL TRAUMA PATIENTS
Gerard P. De Castro, MD, June Hsu, MPH, Grant V. Bochicchio, MD, MPH Kelly Bochicchio, RN, MS, Thomas M. Scalea, MD - University of Maryland School of Medicine
P30. COMBINATION THERAPY WITH CASPOFUNGIN AND VORICONAZOLE IN INVASIVE ASPERGILLOSIS IN SURGICAL PATIENTS.
Christian Geltner, MD, Ingrid Stelzmueller, MD, Cornelia Lass - Floerl, MD, Hugo JR Bonatti MD - Pulmonology, Natters
P31. MOTOR VEHICLE BLUNT SPINAL CORD TRAUMA AND POSTTRAUMATIC INFECTION: WHO IS AT RISK
Douglas R. Fraser, MD, Viktor Y. Dombrovskiy, MD, PhD, MPH, Todd R. Vogel, MD, MPH – University of Medicine and Dentistry of New Jersey - Robert Wood Johnson University Hospital, New Brunswick
P32. MACROPHAGE GENETIC REPROGRAMMING DURING CHRONIC PERITONITIS IS AUGMENTED BY LPS PRETREATMENT
Ziad Kanan, MD, James Peyton, MS, Sarah Gardner, BS, William G. Cheadle, MD - University of Lousville
P33. MAKING SOUND USE OF SCARCE DATA: EXAMINING THE IMPACT OF REPEAT POSITIVE CULTURES IN A DATASET OF MICROBIOLOGY FINDINGS
Stefan Engstrom, Patrick R. Norris, Kenneth A. Debelak, Raymond L. Mernaugh, Sarah D. Valenti, Judith M. Jenkins, Michael B. Daly, Addison K. May, MD, Erik M. Boczko - Vanderbilt University
P34. ACUTE APPENDICITIS - NOT JUST FOR THE YOUNG.
Brian G. Harbrecht, MD, Jason W. Smith, MD, Glen A. Franklin, MD, J. David Richardson, MD - University of Louisville
P35. ALCOHOL ABUSE INCREASED POSTOPERATIVE INFECTION AND LENGTH OF HOSPITAL STAY ON ESOPHAGEAL CANCER RESECTIONS.
Yen - Hong Kuo, ScM, MS, Nasim Ahmed, MD, Yen - Liang Kuo, MD, John M. Davis, MD - Jersey Shore University Medical Center
P36. ROLE OF RESISTANT GRAM-POSITIVE BACTERIA IN TREATMENT FAILURE FOR PERCUTANEOUS DRAINAGE OF POST-OPERATIVE COMPLICATED INTRA-ABDOMINAL INFECTION (CIAI)
Callisia N. Clarke, MD, Yun Miao, MD, PhD, Ross Ristagno, MD, Syed Ahmad, MD, Joseph Solomkin, MD - University of Cincinnati
P37. MUCORMYCOSIS IN A BURN ICU
Mark O. Hardin, MD, John D. Ritchie, MD, Josiah D. Freemyer, Christopher E. White, MD - U.S. Army Institute of Surgical Research (Sponsor: William G. Cheadle, MD)
P38. USING OF A DATA MINING FOR PREDICTION OF INFECTED PANCREATIC NECROSIS.
Andrey A. Litvin, MD, PhD - Gomel Regional Clinical Hospital, Gomel State Medical University, Belarus
P39. IS ANGIOPOIETIN-2 ELEVATED IN TRAUMA PATIENTS WITH EXTRAPULMONARY ALI/ARDS?
Joanne Lomas - Neira, PhD, Rajan Thakkar, MD, Sean Monaghan, MD, Nicholas Carter BA, Alfred Ayala PhD, Daithi Heffernan, MD - Rhode Island Hospital, Alpert School of Medicine at Brown University
P40. INTRACOLONIC VANCOMYCIN FOR SEVERE CLOSTRIDIUM DIFFICILE COLITIS
Peter K. Kim, MD, Heesun C. Um, PharmD, Sal Ahmad, MD, Christina Coyle, MD, Sheldon Teperman, MD, Hugh Boothe, PhD, PharmD - Jacobi Medical Center
P41. MULTIDISCIPLINARY PERFORMANCE IMPROVEMENT (PI) TASK FORCE PROJECT MARKEDLY REDUCED AND ELIMINATED RESISTANT ACINETOBACTER BAUMANII/HAEMOLYTICUS (AB).
Cynthia L. Reigart BSN, Bruce H. Ackerman, PharmD, Meghan Stair - Buchman, BSN, Diane Herder, LPN, Pamela Adams, Christine Young, MBA, Robert E. Guilday, MD, Mary L. Patton, MD, Linwood R. Haith, Jr., MD, William D. Ravreby, MD - Crozer - Chester Medical Center
P42. OUTCOMES ASSOCIATED WITH PROLONGED INFUSIONS OF PIPERACILLIN/TAZOBACTAM IN CRITICALLY ILL PATIENTS.
Daryl Schiller, PharmD, Fariborz Rezai, MD, Michael C. Meadows, MD, Edward H. Gray, DO, Kristin Fless, MD, Ronald S. Chamberlain MD, MPA, Paul C Yodice MD - Saint Barnabas Medical Center (Sponsor: William G. Cheadle, MD)
P43. ASSESSMENT OF THE TREATMENT OF ACINETOBACTER BAUMANNII FOLLOWING THE OUTBREAK OF A MULTI-RESISTANT CLONE AND A VARIANT CLONE IN A BURN TREATMENT CENTER.
Bruce H. Ackerman, PharmD, Pamela Adams, Christine Young, MBA, Cynthia L. Reigart, BSN, Robert E. Guilday, MD, Mary L. Patton, MD, Linwood R. Haith, Jr., MD, William D. Ravreby MD - Crozer - Chester Medical Center
P44. CLOSTRIDIUM DIFFICILE INFECTION MAY REQUIRE SURGICAL MANAGEMENT IN CHILDREN
Jose M. Prince MD, Megan Sippey, BA, John D. Rutkoski, MD, Kevin P. Mollen, MD, Marian G. Michaels, MD, MPH, Brian S. Zuckerbraun, MD, Richard L. Simmons, MD, Barbara A. Gaines, MD - Children's Hospital of Pittsburgh
P45. CLINICAL IMPLICATIONS OF VIRUS-ASSOCIATED NEPHROPATHY AFTER RENAL TRANSPLANTATION.
Helen P. Cathro, MD, Costi D. Sifri, MD, Douglas Keith, MD, Robert G. Sawyer, MD, Timothy L. Pruett MD, Kenneth Brayman, MD, PhD, Hugo JR. Bonatti, MD - Department of Pathology, University of Virginia
P46. COHORTING AND SUPERISOLATION IN A SINGLE INTENSIVE CARE UNIT IN AN EFFORT TO REDUCE PATIENT-TO-PATIENT TRANSMISSION
Laura H. Rosenberger, MD, Tjasa Hranjec, MD, MS, Rosemarie Metzger, MD, MPH, Brian R. Swenson, MD, MS, Robert G. Sawyer, MD - University of Virginia
P47. IMPACT OF TRAUMA CENTER LEVEL IN THE INCIDENCE OF PNEUMONIA FOLLOWING SEVERE HEAD INJURY.
Nasim Ahmed, MD, Yen - Hong Kuo, ScM, MS, Yen - Liang Kuo, MD, John M. Davis. MD - Jersey Shore University Medical Center
P48. PROCALCITONIN IS A USEFUL MARKER TO DIFFERENTIATE BETWEEN INFECTION AND INFLAMMATION IN TRAUMA PATIENTS UNDERGOING ORTHOPEDIC PROCEDURES
Chadi T. Abouassaly, MD, Rondi Kauffman, MD, MPH, Heather Macnew, MD, Elizabeth O'Keefe, PhD, Alison Woodworth, PhD, Addison May, MD - Vanderbilt University Medical Center
P49. CRYPTOSPORIDIOSIS INCREASES TACROLIMUS LEVELS IN SOLID ORGAN RECIPIENTS: EXPERIENCE WITH SEVEN ADULT CASES FROM TWO CENTERS AND REVIEW OF THE LITERATURE.
Hugo J.R. Bonatti, MD, Luis F. Barroso, MD, Robert G. Sawyer, MD, Kenneth Brayman, MD, Camielle N. Kotton, MD, Costi D. Sifri, MD - University of Virginia
P50. WITHDRAWN
P51. ACINETOBACTER BAUMANNI: A COLLATERAL DAMAGE PATHOGEN. A REVIEW OF RISK FACTORS AND CURRENT TREATMENT RECOMMENDATIONS.
Kenji Kamanaka, BA, Michael C. Meadows, MD, Ronald S. Chamberlain MD, MPA - University of Medicine and Dentistry of New Jersey (Sponsor: William G. Cheadle, MD)
P52. SURGICAL SITE INFECTION IN LAPAROSCOPIC INGUINAL HERNIORRHAPY SURGICAL SITE INFECTION IN LAPAROSCOPIC INGUINAL HERNIORRHAPY
Maris S. Jones, MD, Charles R. St. Hill, MD, Shawn Tsuda, MD, Annabel E. Barber, MD - University of Nevada School of Medicine
P53. A MULTIDISCIPLINARY TEAM APPROACH TO REDUCING CLBSI IN THE ICU
Lynne W. Campbell, BSN, MSN, Jeanne Zack, PhD, Nancy Hansen, BSN, Linda Odnoha, BSN, Kevin Stuckert, MHA, Tracy Hathorn, RD, Susan Tuttle, PharmD, Marilyn Kole, MD, Jeffrey M. Scott, DO - Lee Memorial Health System
P54. SURGICAL INFECTION AND RISK FACTORS IN A GENERAL SURGERY SERVICE: A PROSPECTIVE STUDY.
Pablo Vazquez Aragon, Pedro Cascales Sanchez, Maria Teresa Villar Canovas, Antonio Serafin Valero Linan, Juan Luis Rueda Martinez, Antonio Prat Calero, Maria Abad Martinez - General and University Hospital - Albacete, Spain
P55. SCEDIOSPORIUM BRAIN ABSCESSES IN A PATIENT WITH A PATENT FOREMEN OVALE CAUSED BY SINUSITIS AND FUNGAL PNEUMONIA FOLLOWING A WORK-RELATED BOILER EXPLOSION.
Linwood R. Haith Jr. MD, Bruce H. Ackerman, PharmD, Heidi Hornbeek, MD, Mary L. Patton, MD, Robert E. Guilday, MD - Crozer - Chester Medical Center
P56. LIPOPOLYSACCHARIDE ALTERS THE GENETIC EXPRESSION OF KEY ENZYMES IN CERAMIDE METABOLISM
Mae F. Cantos, BSc, MD, Andras Kapus, MD, PhD, Menachem Ailenberg, PhD, Ori D Rotstein, MD – University of Toronto, St. Michael's Hospital
P57. A CASE OF CAT BITE INFECTION AS POLYMICROBIAL INFECTION CAUSED BY PASTEURELLA MULTOCIDA AND PREVOTELLA SPECIES
Yuka Yamagishi, MD, Hiroshige Mikamo, MD, PhD - Aichi Medical University
P58. NASAL SWAB SPECIMENS THAT ARE ROUTINELY COLLECTED TO SCREEN FOR MRSA IN INTENSIVE CARE UNITS CAN BE USED TO PREDICT THE PRESENCE OF MRSA IN CLINICAL CULTURES.
Matthew C. Byrnes, MD, Titi Adegboyega, BA, Andrew Riggle, BA, Gregory Beilman, MD, Jeffrey Chipman, MD - University of Minnesota
P59. ABDOMINAL WALL WOUNDS SURROUNDING HIGH OUTPUT ENTEROCUTANEOUS FISTULAS CAN BE SUCCESSFULLY SKIN GRAFTED.
Matthew Byrnes, MD, Andrew Riggle, BA, Greg Beilman, MD, Jeffrey Chipman MD - University of Minnesota
P60. CALCIFIC UREMIC ARTERIOLOPATHY-A COMBINED AGGRESSIVE CONJOINT NEPHROLOGY/BURN SURGERY MANAGEMENT
Linwood R. Haith, MD, Erica R. Podolsky, MD, Robert E. Guilday, MD, Mary Lou Patton, MD, Surekha Neeli, MD, Nathan Okechukwu, MD - Crozer Chester Medical Center
P61. TUMESCENT ANTIBIOTIC DELIVERY FOR SSI PROPHYLAXIS
Jeffrey A. Klein MD, MPH, Atoussa Cameron, RN, JoAnn Coker, RN, Loralie Langman, MD, Christine Snozek, MD - University of California, Riverside
P62. INCREASED INFECTIONS ARE ASSOCIATED WITH NON-OPERATIVE TRANSFUSIONS IN BURN PATIENTS
Joseph A. Posluszny Jr., MD, Chindo Hicks, PhD, Ravi Shankar, PhD, Richard L. Gamelli, MD - Loyola University Medical Center, Case Western Reserve University School of Medicine
P63. SINGLE CELL METAGENOMIC ANALYSIS OF GUT BACTERIA FROM HUMAN INFANTS WITH NECROTIZING ENTEROCOLITIS
Valeriy Poroyko, PhD, John Alverdy, MD, Donald Liu, MD, Michael Morowitz MD - University of Chicago
17:30 - 18:30 SIS ANNUAL BUSINESS MEETING
Lena M. Napolitano, MD, Presiding		 Ballroom 1 - 2
19:00 - 20:00 RECEPTION Ballroom Foyer
20:00 - 22:00 AWARDS BANQUET Ballroom 3 - 4
 
Tuesday, April 20, 2010
06:30 - 07:45 AM SUNRISE SYMPOSIUM III
Reducing Ventilator - Associated Pneumonia - Thinking Outside the Bundle
Moderator: TBD
Faculty: M. Kollef, MD, L. M. Napolitano, MD, J. Restrepo, MD		 Ballroom 3 - 4
08:00 - 10:00 COMBINED SESSION I
Mechanistic Insights into the Development of Surgical Infection (Papers 41 - 47)
Moderators: John C. Alverdy, MD and Nicholas Namias, MD, MBA		 Ballroom 1 - 2
41. TRAFFICKING OF THE TLR4 INHIBITOR IRAK-M VIA NOD2 LIMITS TLR4 RESPONSIVENESS IN INTESTINAL EPITHELIAL CELLS
Matthew D. Neal, MD, Amin Afrazi, BS, Chhinder Sodhi, PhD, David J. Hackam, MD, PhD - Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center
Discussant: David Greenhalgh, MD
42. SINGLE NUCLEOTIDE POLYMORPHISM A829G IN THE TRANSACTIVATION DOMAIN OF THE HUMAN GLUCOCORTICOID RECEPTOR PRODUCES HYPERACTIVITY
Kelly Tung, MD, MS, Tajia L. Green, BS, Sally T. Nguyen, BS, Debora Lim, BS, Kiho Cho, DVM, PhD, David G Greenhalgh, MD - Shriners Hospitals for Children Northern California/University of California, Davis Medical Center
Discussant: Craig M. Coopersmith, MD
43. TERMINATION OF HAND HYGIENE SURVEILLANCE IS ASSOCIATED WITH INCREASED NOSOCOMIAL INFECTIONS IN THE SURGICAL INTENSIVE CARE UNIT
Dorothy W. Bird, MD, Dale Ford, RN, MPH, Carol Sulis, MD, Peter A. Burke, MD, Suresh Agarwal, MD - Boston University Medical Center
Discussant: Sandra M. Swoboda, RN, MSN
44. ANTIBIOTIC TIME-LAG COMBINATION THERAPY WITH FOSFOMYCIN FOR PATIENTS WITH POSTOPERATIVE INTRA-ABDOMINAL ABSCESS.
Shinya Kusachi, MD, PhD, Jiro Nagao, MD, PhD, Junko Sato, PhD, Tomoaki Saito, MD, Masashi Uramatsu, MD, Yoichi Nakamura, MD, PhD, Yoshihisa Saida, MD, PhD, Manabu Watanabe, MD, PhD, Yasushi Okamoto, MD, PhD, Koji Asai, MD, PhD, Toshiyuki Enomoto, MD, PhD, Ryohei Watanabe MD, Yoichi Arima, MD, PhD, Yuichi Yoshida, MD, PhD - Toho University Ohashi Hospital
Discussant: Patrick O’Neill, MD
45. CHANGES IN LEUKOCYTE COUNT ARE MORE IMPORTANT IN PREDICTING INFECTION THAN ABSOLUTE LEUKOCYTE COUNT IN CRITICALLY ILL TRAUMA PATIENTS
Jeffrey W. Carter, MD, William H. Leukhardt, MD, Joseph F. Golob, MD, Adam M. Fadlalla, PhD, Jeffrey A. Claridge, MD, MS - MetroHealth Medical Center
Discussant: Michael J. Morowitz, MD PhD
46. THE INFLAMMATORY RESPONSE IN COMBAT WOUNDS IS ASSOCIATED WITH CRITICAL COLONIZATION
Trevor S. Brown, PhD, Jason S. Hawksworth, MD, Forest R. Sheppard, MD, Douglas K. Tadaki, PhD, Eric A. Elster, MD - Naval Medical Research Center, Bethesda
Discussant: Laura Moore, MD
47. DOES WITHHOLDING EARLY INTRAVENOUS FAT EMULSION FROM PARENTERAL NUTRITION REDUCE INFECTIONS DURING CRITICAL ILLNESS?
Anthony T .Gerlach, PharmD, Claire V. Murphy, PharmD, BCPS, Sheela Thomas, MS, RD, LD, Lydia Pourzanjani, RD, LD, Stan Stawicki, MD, Steven Steinberg, MD, Melissa Whitmill, MD, Charles H. Cook MD* - The Ohio State University
Discussant: Kenneth Kudsk, MD
10:00 - 10:15 BREAK–VISIT EXHIBITS Ballroom Foyer
10:30 - 12:30 COMBINED SESSION II
Clinical Investigations into Surgical Infections (Papers 48 - 56)
Moderators: Pamela A. Lipsett, MD and John E. Mazuski, MD, PhD		 Ballroom 1 - 2
48. HYPOXIA-INDUCED UPREGULATION OF AUTOPHAGY IN MOUSE HEPATOCYTES IS DEPENDENT ON CASPASE-1
Qian Sun, MD, Timothy R. Billiar, MD, Melanie J. Scott, MD, PhD - University of Pittsburgh
Discussant: Daniel L. Traber, PhD
49. MRSA CARRIER STATUS OF PATIENTS PRESENTING WITH SKIN AND SOFT TISSUE INFECTIONS.
Carlos H. Palacio, MD, Daniel M. Musher, MD, Ricardo E. Nuila, MD, Anuradha Subramanian, MD, David M. Green, MD, BS, Samir S. Awad, MD - Baylor College of Medicine
Discussant: Saman Arbabi, MD
50. MULTIDRUG-RESISTENT PATHOGENS AND INITIAL EMPIRIC ANTIBIOTIC THERAPY FOR PNEUMONIA IN THE TRAUMA VERSUS SURGICAL INTENSIVE CARE UNIT
Robert D. Becher, MD, Jason Hoth, MD, PhD, Lucas P. Neff, MD, Jerry J. Rebo, PharmD, Robert S. Martin, MD, Preston Miller, MD - Wake Forest University Medical Canter
Discussant: Charles Adams, MD
51. SIGNIFICANT DIFFERENCES IN SERUM CYTOKINE LEVELS BETWEEN INFECTED ELDERLY AND YOUNGER ADULTS ADMITTED FOR CRITICAL CARE
Tjasa Hranjec, MD, MD, Brian R. Swenson, MD, MS, Lesly A. Dossett, MD, Rosemarie Metzger, MD, MPH, Laura H. Rosenberger, MD, Amani D. Politano, MD, Kimberly A. Popovsky, RN, Addison K. May, MD, Robert G. Sawyer, MD - University of Virginia
Discussant: Raul Coimbra, MD, PhD
52. SPECTRUM OF PATHOGENS ASSOCIATED WITH INTRAABDOMINAL INFECTION AFTER PANCREAS TRANSPLANTATION WITH ENTERIC DRAINAGE.
Christian Margreiter, MD, Natalie Berger, MD, Reinhold Kafka - Ritsch, MD, Raimund Margreiter, MD, Wolfgang Steurer, MD, Johann Pratschke, MD, Walter Mark, MD, Hugo J. R. Bonatti, MD - Surgery, Innsbruck Medical University
Discussant: John Mihran Davis, MD
53. ORTHOPEDIC INJURIES - IT DOESN'T COME OUT IN THE WASH
Claudia E. Goettler, MD, Lisa Schlitzkus, MD, Scott G. Sagraves, MD, Christopher C. Hasty, MD, Michael F. Rotondo, MD - East Carolina University, Brody School of Medicine
Discussant: Jeffrey Chipman, MD
54. PLATELET FACTOR 4 (PF4; CXCL4) PROMOTES REMOTE LUNG INJURY FOLLOWING MESENTERIC ISCHEMIA AND REPERFUSION.
Peter H. Lapchak, MSc, PhD, Peter Karian, Poonam Rani, MSc, Lakshmi Kannan, PhD, Jurandir J. Dalle Lucca, MD, George C. Tsokos, MD - Beth Israel Deaconess Medical Center and Harvard Medical School
Discussant: Charles H. Cook, MD
55. TWELVE-YEAR EXPERIENCE WITH SEVERE CANDIDA INFECTIONS: DECREASING MORTALITY, EVOLVING EPIDEMIOLOGY, AND EMERGENCE OF NEW ANTIFUNGALS
Carlos A. Tache Leon, MD, Tjasa Hranjec, MD, Swenson Brian, MD, Kimberly A. Popovsky, RN, Robert G. Sawyer, MD - University of Virginia
Discussant: Annabel Barber, MD
56. BLADDER PRESSURE MEASUREMENTS ARE AN INDEPENDENT PREDICTOR OF UTI IN TRAUMA PATIENTS
Therese M. Duane, MD, Holly Brown, BS, Luke G. Wolfe, MS, Ajai K. Malhotra, MD, Michel B. Aboutanos, MD, MPH, Rao R. Ivatury, MD - Virginia Commonwealth University
Discussant: Preston Roy Miller III, MD
12:30 MEETING ADJOURNMENT


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