Jared Huston, MD
Title: Assistant Professor of Surgery
Institution: Hofstra North Shore-LIJ School of Medicine
Clinical Specialty: Trauma and Acute Care Surgery
Research Interest: Neuroimmunology, Shock, Sepsis
SIS Fellowship Mentor: Kevin J. Tracey MD
SIS Mentor: Philip S. Barie MD
SIS Junior Faculty Project Title: Cholinergic Regulation of ANP during sepsis
Brief Description of the significance of your research:
Sepsis is a leading cause of mortality worldwide. Scientific advances have identified novel mechanisms that regulate immune responses during sepsis. The cholinergic anti-inflammatory pathway is a brain-to-immune mechanism that inhibits pro-inflammatory cytokine production, preserves vital organ function and reduces lethality during experimental shock and sepsis. Cholinergic anti-inflammatory signaling is dependent upon a vagus nerve pathway to spleen, where acetylcholine-synthesizing T cells modulate cytokine-producing tissue macrophages via the α7 nicotinic acetylcholine receptor subunit (α7nAChR).
Atrial natriuretic peptide (ANP) is classically thought of as a cardiovascular hormone produced by the heart. Recent studies suggest that splenic macrophages produce ANP, and ANP release from spleen during rodent end--otoxemia contributes to hypotension and shock. Moreover, clinical studies indicate that circulating natriuretic peptide concentrations are independent predictors of sepsis mortality. The pathophysiologic mechanisms underlying this association remain unknown.
Our research aims to elucidate the precise role of ANP production during lethal sepsis and in the context of cholinergic anti-inflammatory signaling. Our findings will provide important information regarding the molecular basis of cholinergic anti-inflammatory signaling, and can help translate the beneficial effects of cholinergic stimulation into clinical practice for our patients with lethal sepsis.
How did you get involved in surgical infections research and the SIS?: Through Dr. Barie when I trained as a surgical resident with him at New York Presbyterian Hospital
When did you join? 2009
What does the SIS mean to you? The two characteristics that come to mind when I think of the SIS are friendship and mentorship. Numerous individuals within the SIS have had a major impact upon my early surgical career, and I am very grateful for their unwavering encouragement and support.
What does the Junior Faculty award mean to you? I am honored to receive the 2013 Junior Faculty Award from the SIS Foundation. The Surgical Infection Society has a long and proud tradition of supporting young investigators at the resident, fellow and junior faculty levels. Many of these previous awardees have both contributed significantly to the field of surgical science, and helped strengthen and lead the SIS, including our current President Dr. Sawyer. I hope to add to these impressive accomplishments in the future.
What suggestions would you give to residents trying to pursue a research career? Develop an interest in a particular field or specialty, seek out and align yourself with colleagues who have similar research interests and are interested in helping you, be prepared for setbacks, obstacles and failures, be persistent and believe in yourself, take risks and enjoy the ride!