Global Alliance for Infections in Surgery

    by Massimo Sartelli



    U.S. Antibiotic Awareness Week




    U.S. Antibiotic Awareness Week

    November 13-19, 2017

    “Download "A Global Declaration on Appropriate Use of

    Antimicrobial Agents across the Surgical Pathway””

    “Download Drs. Itani and May Editorial in Surgical Infections"










    SIS Endorses and Participates In the CDC’s “Get Smart About Antibiotics” Initiative

    Medicine may be losing the battle to treat serious infections-new antibiotics are few and far between, and bacteria are becoming increasingly resistant to the antibiotics that are still usable. That’s why it is incumbent upon every practitioner, regardless of specialty, to use carefully the antimicrobial agents we do have. This antibiotic stewardship is crucially important so that infections are treated (and prevented) timely and effectively with antibiotics, but also so that misuse and overuse become a thing of the past.

    A core mission of SIS is to work both to prevent and treat infections of surgical patients. Rational and parsimonious antibiotic use is an important part of infection management, one that SIS has been espousing for at least the last 16 years, since SIS Past-President, SIS Foundation Executive Director, and Founding Editor of Surgical Infections Philip S. Barie published Modern Surgical Antibiotic Prophylaxis and Therapy-Less is More in the inaugural issue of the journal. [1].

    Recently, SIS Past-President Robert G. Sawyer led a group that published the SIS-endorsed STOP-IT trial, which demonstrated that four days of antimicrobial therapy was equivalent to an eight-day course for treatment of complicated intra-abdominal infection when surgical source control was adequate [2]. Post-hoc analyses have suggested that neither obese patients [3], patients presenting with sepsis [4], those with polymicrobial infections [5] or risk factors for complications [6], nor those undergoing initial percutaneous drainage [7] require a longer duration of therapy. Nor does addition of vancomycin to the regimen provide any additive benefit [8]. A video interview with Doctor Sawyer can be found here.

    The principles of stewardship apply equally to the prescribing of surgical antibiotic prophylaxis [1]. Published in 2013 by SIS in collaboration with the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, and the Society for Healthcare Epidemiology of America, revised guidelines are available for the effective and safe use of prophylactic antibiotics [9]. SIS considers this document a “must-read, must-heed” for all surgeons [10].

    In conjunction with this important CDC initiative, SIS is pleased to announce the e-publication in Surgical Infections, in conjunction with the World Society for Emergency Surgery, of a position statement on antimicrobial stewardship in surgery [11]. Adhering to the principles of antibiotic stewardship in surgical practice is crucial for the optimal care of the surgical patient.

    If you are reading this as a patient or a loved one, click here for a link to answers to frequently asked questions about antibiotic stewardship. If you are a surgical trainee or part of a surgical team, link here to the SIS YouTube channel, where you will find a series of short video presentations about maintaining the operating room environment. After all, antibiotics alone are not enough to prevent infection following surgery.


    1. Barie PS. Modern surgical antibiotic prophylaxis and therapy--less is more. Surg Infect (Larchmt). 2000;1:23-29.
    2. Sawyer RG, Claridge JA, Nathens AB, et al. Trial of short-course antimicrobial therapy for intraabdominal infection. N Engl J Med 2015;372:1996-2005.
    3. Dietch ZC, Duane TM, Cook CH, et al. Obesity is not associated with antimicrobial treatment failure for intra-abdominal infection. Surg Infect (Larchmt).2016;17:412-421.
    4. Rattan R, Allen CJ, Sawyer RG, et al. Patients with complicated intra-abdominal infection presenting with sepsis do not require longer duration of antimicrobial therapy. J Am Coll Surg 2016; 222:440-446.
    5. Shah PM, Edwards BL, Dietch ZC, et al. Do Polymicrobial intra-abdominal infections have worse outcomes than monomicrobial intra-abdominal infections? Surg Infect (Larchmt) 2016;17:27-31.
    6. Rattan R, Allen CJ, Sawyer RG, Patients with risk factors for complications do not require longer antimicrobial therapy for complicated intra-abdominal infection. Am Surg 2016;82:860-866.
    7. Rattan R, Allen CJ, Sawyer RG, et al. Percutaneously drained intra-abdominal infections do not require longer duration of antimicrobial therapy. J Trauma Acute Care Surg. 2016;81:108-113.
    8. Sanders JM, Tessier JM, Sawyer RG, et al. Inclusion of vancomycin as part of broad-spectrum coverage does not improve outcomes in patients with intra-abdominal infections: A post hoc analysis. Surg Infect (Larchmt) 2016 Aug 2. [Epub ahead of print].
    9. Bratzler DW, Dellinger EP, Olsen KM. et al. Clinical practice guidelines for antimicrobial prophylaxis in surgery. Surg Infect (Larchmt).2013;14:73-156.
    10. Barie PS. Guidelines for antimicrobial prophylaxis in surgery: a must-read, must-heed for every surgeon. 2013;14:5-7.
    11. Sartelli M, Duane TM, Catena F, et al.. Antimicrobial stewardship: A call to action for surgeons. Surg Infect (Larchmt) 2016 Nov 9 [Epub ahead of print]. 


    What is Antibiotic Stewardship?

    Novel Method Allows Proof of Superiority in Antibiotic Trials Using Smaller Cohorts

    Dr. Arthur Celestin, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA

    No Difference in Outcomes of Fungal IAI with a 4 Day Treatment Regimen

    Dr. Nathan Elwood, University of Virginia

    Age and Its Impact on Outcomes with Intraabdominal Infection

    Dr. Drew Farmer, Baylor University Medical Center at Dallas

    Duration of Antimicrobials For Intraabdominal Infection Does Not Prevent Treatment Failure Among High-Risk Patients

    Dr. Taryn Hassinger, University of Virginia Health System



    American College of Surgeons and Surgical Infection Society Announce New Guidelines for the Prevention and Treatment of Surgical Site Infections


    Consensus recommendations identify interventions targeted at reducing the risk of infection after an operation

    CHICAGO (December 1, 2016): Newly released guidelines for the prevention, detection, and management of surgical site infections (SSIs) issued by the American College of Surgeons and the Surgical Infection Society provide a comprehensive set of recommendations clinicians can use to optimize surgical care and educate patients about ways to contribute to their own well-being. The guidelines are based on a review of the best available research and clinical practice experience and update previous sets of recommendations on detecting and preventing SSIs from professional clinical and hospital societies.  The guidelines were presented at the Surgical Infection Society meeting, Palm Beach, Fla., in May 2016 and are published as an “article in press” on the Journal of the American College of Surgeons website in advance of print publication.

                SSIs are the most common type of hospital-acquired infection.  SSIs account for 20 percent of all infections that occur in the hospital setting.1  Although most patients recover from an SSI without any long-term consequences, they are at a 2- to 11-fold increased risk of mortality.2

                Furthermore, SSIs are the most costly of all hospital-acquired infections.  With an annual estimated overall cost of $3 to $5 billion in the U.S., SSIs are associated with a nearly 10-day increased length of stay and an increase of $20,000 in the cost of hospitalization per admission.3

                As many as 60 percent of SSIs are considered to be preventable.4  Now that the Centers for Medicare and Medicaid Services no longer pays additional amounts for the cost of treating conditions acquired in a hospital, SSIs have been targeted not only to improve clinical quality, but also to protect hospital reimbursement.

                The new guidelines were developed by investigators from the Board of Governors of the American College of Surgeons and the Surgical Infection Society.  Evidence from the clinical literature was reviewed by expert panels from both societies as well as outside content experts to reach consensus across the full course of treatment of surgical patients, including prehospital preparation, hospital interventions, and post-discharge care.

                “The guidelines give clinicians step-by-step ways to address SSIs, because there is no single specific fix to the problem and there are many factors in the processes of care,” said principal author Therese M. Duane, MD, MBA FACS, FCCM, vice-chair of quality and safety of the department of surgery and medical director of acute care surgical research, Texas Health Care, at John Peter Smith Health Network, Fort Worth.

                Some of the new guidelines call for a change in hospital management to reduce the risk of SSIs.  While the presence of diabetes and use of diabetic medications are considered to be risk factors for SSIs, studies show that control of high blood sugar is more important immediately before an operation than over the long term.  Research indicates that high blood sugar levels during an operation increase the risk of an SSI; excessively low blood sugar levels increase the risk of adverse outcomes and the frequency of hypoglycemic episodes, but they do not reduce the risk of an SSI.  The consensus guidelines therefore set target blood glucose levels at 110-150 mg/dL for all patients regardless of their diabetic status in the immediate preoperative period.

                A change in lifestyle habits can help patients reduce their risk of SSI.  Recent research corroborates that smokers have the highest risk of SSIs and former smokers are at greater risk of infection than nonsmokers.  A consensus guideline therefore encourages surgeons to advise their patients to stop smoking four to six weeks before an operation.

                “An important message coming out of these guidelines is that patients have a major role in their own outcomes.  That message cannot be underscored enough.  Smoking cessation, blood glucose control for diabetic patients, and weight loss are some of the things patients can do to prevent an SSI,” Dr. Duane said.

                Some aspects of surgical management still do not have enough robust, high-quality data to warrant clear recommendations, such as optimal wound care after discharge.

                “These days, you can do all the right things preoperatively and in the hospital, but if clinicians do not give patients sufficient guidance about wound care and follow-up once they leave the hospital, patients can set themselves up for infections down the line.  Trying to make sure patients and their families optimize wound care after they go home is integral to the success of their treatment,” Dr. Duane said.

                The recommendations on reducing SSIs serve as starting points.  These points provide benchmarks against which clinicians can track and trend their outcomes, and they identify for researchers the areas of surgical care that require more study.

                “The guidelines show how we in the surgical community can make an impact from a practice and research standpoint,” Dr. Duane said.

                Other study coauthors include Kristen A. Ban, MD; Joseph P. Minei, MD, FACS; Christine Laronga, MD, FACS; Brian G. Harbrecht, MD, FACS; Eric H. Jensen, MD, FACS; Donald E. Fry, MD, FACS; Kamal M. F. Itani, MD; E. Patchen Dellinger, MD,FACS; and Clifford Y. Ko, MD, FACS.

                Note: “FACS” designates that a surgeon is a Fellow of the American College of Surgeons. 


    Citation: American College of Surgeons and Surgical Infection Society: Surgical Site Infection Guidelines, 2016 Update.  Journal of the American College of Surgeons. DOI: http://dx.doi.org/10.1016/j.jamcollsurg.2016.10.029.

    [1] Anderson DJ et al.  Strategies to Prevent Surgical Site Infections in Acute Care Hospitals: 2014 Update.  Infection Control & Hospital Epidemiology 2014; 35(06):605-627.

    2 Bratzler DW et al.  Clinical practice guidelines for antimicrobial prophylaxis in surgery. American Journal of Health-System Pharmacy 2013; 70(3)195-283.

    3 Mangram AJ et al.  Guideline for Prevention of Surgical Site Infection, 1999.  Infection Control and Hospital Epidemiology 1999; 20(4):247-278.

    4 Magill SS et al.  Multistate point-prevalence survey of health-care associated infections.  NEJM 2014;370(13):1198-1208.