Full Program

Annual Meeting

Wednesday, April 15, 2015
19:00-21:30	President's Dinner By invitation	Pagoda Lawn

Thursday, April 16, 2015
06:30-07:30	Breakfast	Garden Lawn
07:00-07:30	Executive Council Breakfast (By invitation)	Georgian
07:30-11:30	Executive Council Meeting (By invitation)	Georgian
7:30- 11:30	SURGICAL INFECTION UPDATE SYMPOSIUM	Ballroom
	BIOLOGY OF SEPSIS and PHARMACOLOGY
07:30-0745	Microbiology of surgical pathogens: Gram-positive cocci	Lena Napolitano
07:45-08:00	Biology and metabolism of sepsis	Matthew Rosengart
08:00-08:15	Organ physiology and multiple organ failure/dysfunction	John Marshall
08:15-08:30	Antimicrobials and antibiotic PDs: Anti-staphylococcal drugs	Pamela Lipsett
08:30-09:45	Q and A session
	RISK PREVENTION/PROPHYLAXIS
08:45-09:05	New intra-abdominal infection guidelines	John Mazuski
09:00-09:15	Clostridium difficile infections	Brian Zuckerbraun
09:15-09:30	Antibiotic stewardship	Robert Sawyer
09:30-09:45	Q and A session
09:45-10:00	BREAK
	SPECIFIC INFECTIONS
10:00-10:15	Necrotizing soft tissue infections	Addison May
10:15-10:35	DEBATE: Acute cholecystitis: Operate? Drain percutaneously? Soumitra Eachempati vs. Saman Arbabi
10:35-10:55	DEBATE: Acute diverticulitis: Lavage or resect? Anastomose or divert? Lillian Kao vs. Christine Cocanour
10:55-11:15	DEBATE: Acute appendicitis: Antibiotics or appendectomy? Therese Duane vs. E. Patchen Dellinger
11:15-11:30	Q and A session
11:30- 11:45	Nominating Committee (By invitation)	Georgian
12:00-13:00	LUNCHEON SYMPOSIUM (Industry-sponsored; not part of scientific program)	Garden Lawn
13:00-16:45	PLENARY SYMPOSIUM The Art and Science of Surgical Infections Papers 1 - 10 Moderators: Nicholas Namias, MD, MBA, and John C. Alverdy, MD	Ballroom
	O1. Pathway Analysis of the Intestinal Transcriptome of Mice Rescued From Sepsis via a Fecal Microbiota Transplant Demonstrates a Role for IL22. Monika Krezalek (Resident), presenting. University of Chicago. Discussant: Michaela West, MD, PhD
	O2. Statewide Evaluation of Intra-wound Antibiotics in Spine Surgery Patients: A Report from the SCOAP-CERTAIN Collaborative. Anne Pugel, (Resident) presenting. University of Washington. Discussant: Robert G. Sawyer, MD
	O3. Microbial Changes in Opioid-Induced Colonic Anastomotic Leak. Baddr Shakhsheer (Resident), presenting. University of Chicago. Discussant: Philip S. Barie, MD, MBA
	O4. Colonic Lavage for the Treatment of Severe C. difficile Infections: The London Protocol. Kalvin Lung, (Resident) presenting. University of Western Ontario. Discussant: Pamela A. Lipsett, MD, MHPE
	O5. Hepatocytes are a Dominant Source Of HMGB1 in the Innate Immune Response During Sepsis. Meihong Deng, (New Member) presenting. University of Pittsburgh. Discussant: Henri R. Ford, MD, MHA
	O6. Obesity is not Associated with Antimicrobial Treatment Failure for Intra-Abdominal Infection. Zachary Dietch (Resident), presenting. University of Virginia. Discussant: E. Patchen Dellinger, MD
	O7. Deficiency in Oncostatin M Receptor Results in Improved Survival in Older Mice Following Sepsis Through Down-Regulation of IL-10. Saad Salim (New Member), presenting. University of Alberta. Discussant: Brian Zuckerbraun, MD
	O8. Novel Predictors of Burn Wound Infections in Severely Burned Children. Arham Ali (Resident), presenting. University of Texas Medical Branch. Discussant: Basil A. Pruitt, Jr., MD
	O9. Repair of the Enteric Nervous System through Vagal-Mediated Expansion of Neural Stem Cells. Simone Langness (Resident), presenting. University of California, San Diego. Discussant: William G. Cheadle, MD
	O10. Risk-Adjustment for Determining Surgical Site Infection in Colon Surgery: Are we Using Appropriate Variables? Sydne Muratore, presenting. University of Minnesota. Discussant: Donald E. Fry, MD
16:45-17:30	"SIS WAIT FOR IT Planning Study"-Robert Sawyer, MD	Library
16:45-17:30	Committee Meetings	Garden Lawn
17:30-18:15	Surgical Infections Editorial Reception (By invitation)	Balcony B
18:15-19:00	SIS Foundation Board Meeting (By invitation)	Library
19:00-20:30	Welcome Reception	Waterfall

Friday, April 17, 2015
06:30-08:00	Breakfast	Garden Lawn
07:00-08:00	Breakfast Symposium (Industry-sponsored; not part of scientific program)	Garden Lawn
08:00-09:45	PARALLEL SESSION I Clinical Research (Papers 11-15) Moderators: Daithi S. Heffernan, MD, and Sandra Swoboda, RN, MSN	Ballroom BCD
	O11. RibScore: A Novel Radiographic Score based on Fracture Pattern that Predicts Pneumonia, Respiratory Failure, and Tracheostomy. Brandon Chapman (Resident), presenting. University of Colorado-Denver. Discussant:Addison K. May, MD
	O12. Top Guns: The Maverick and Goose of Empiric Therapy. Stephen Davies (Resident), presenting. University of Pittsburgh. Discussant: Jeffrey L. Johnson, MD
	O13. Contact Isolation In Trauma Patients: An Analysis Of Infectious Complications. Mark Hamill, presenting. University of Virginia. Discussant: Sandra M. Swoboda, MSN, RN
	O14. Comparing Readmissions and Infectious Complications of Blunt Splenic Injuries Using a Statewide Database. Olubode Olufajo presenting. Brigham and Women's Hospital. Discussant: Daithi S. Heffernan, MD
	O15. Impact of Type of Insurance on Infection Rates after Trauma. Jaswin Sawhney (Resident), presenting. Brown University. Discussant: Amy A. McDonald, MD/em>
08:00-09:45	PARALLEL SESSION II Basic Science (Papers 16-20) Moderators: Carl Hauser, MD and Brian Eliceiri, PhD	Ballroom AE
	O16. Hypothermia Prolongs the Survival of Rats with Severe Septic Shock by Inhibiting the Splenic Release of Neutrophils and Monocytes. Rhett N. Willis (Resident), presenting. University of Virginia. Discussant: Kevin P. Mollen, MD
	O17. Listeria monocytogenes Inhibits Th17 Responses Through TLR2 Signaling. Song Liu, presenting. Medical School of Nanjing University. Discussant: Meihong Deng, MD
	O18. Mitochondrial ROS Induces Cardiac Inflammation via Damage in Mitochondrial DNA and Stimulation of RAGE Pathway in a Pneumonia-related Sepsis Model. Qun (Sophia) Zang, presenting. University of Texas- Southwestern. Discussant: Carl Hauser, MD
	O19. Blue Light Reduces Organ Injury During Critical Illness. Du Yuan (Resident), presenting. University of Pittsburgh. Discussant: Nicholas Namias, MD, MBA
	O20. The Collagenolytic Activity of Fecal Enterococcus faecalis Predicts Anastomotic Leak: Development of a Novel Assay to Clinically Track the Collagenolytic Phenotype. Kristina Guyton (Resident), presenting. University of Chicago. Discussant: Matthew R. Rosengart, MD, MPH
09:45-10:00	BREAK-Visit the Exhibits
10:00-11:00	William A. Altemeier Memorial Lecture. "Evolving Epidemiology of MOF into PICS" Frederick A. Moore, MD, FACS, MCCM Professor and Chief of Acute Care Surgery, University of Florida Health	Ballroom BCD
11:00-12:00	Surgical Infection Society Presidential Address "Let’s Go Far" John C. Alverdy, MD The Sara and Harold Lincoln Thompson Professor and Executive Vice Chair Department of Surgery, University of Chicago Medicine	Ballroom BCD
12:00-13:15	<strong (Industry-sponsored; not part of scientific program)	Garden Lawn
13:30-15:15	UPDATE SYMPOSIUM I International Topics in Surgical Infections Moderator: Joseph Solomkin, MD	Ballroom BCD
	Topic 1: Strategies to Prevent SSI in Japan - Keita Morikane Topic 2: Approach to Surgical Site Infection in Nicaragua - Andrew Stephen Topic 3: Surgical Infections in the Deployed Setting - David Blake Topic 4: Surgical site infection rates following cesarean section in sub-Saharan Africa: A focus point for guideline-based intervention - Joseph Solomkin
15:15-13:30	Break-Visit the Exhibits
15:30-17:00	PARALLEL SESSION III Clinical Research (Papers 21-26) Moderators: Samir S. Awad, MD and Heather L. Evans, MD, MS	Ballroom BCD
	O21. Preoperative Antisepsis Protocol Compliance and the Effect on Bacterial Load Reduction. Alison Smith (Resident), presenting. Tulane University. Discussant: Jared Huston, MD
	O22. Necrotizing Enterocolitis: Does Perforation Matter? Varun Bhalla, presenting. Children’s National Medical Center. Discussant: Catherine J. Hunter, MD
	O23. Abdominal Compartment Syndrome, Cerebral Infarction, and Acute Respiratory Distress Syndrome are the Biggest Modifiable Risk Factors for Surgical Site Infections in Blunt Traumatic Hemorrhagic Shock. John Hwabejire (Resident), presenting. Howard University. Discussant: Lena M. Napolitano, MD
	O24. Do Polymicrobial Intra-Abdominal Infections have Worse Outcomes than Monomicrobial Intra-Abdominal Infections? Puja M. Shah (Resident), presenting. University of Virginia. Discussant: Lillian Kao, MD/em>
	O25. The Influence of Beta-Lactam Prescribing Patterns on Resistance Rates among Various Adult ICU Populations. Sara E Parli, presenting. University of Kentucky. Discussant: Jeffrey M. Tessier, MD
	O26. Prophylactic Gentamicin is Not Associated with Acute Kidney Injury in Patients with Open Fractures. Jeffrey M. Tessier, presenting. JPS Health Network. Discussant: Heather L. Evans, MD
15:30-17:00	PARALLEL SESSION IV Basic Science (Papers 27-32) Moderators: Matthew R. Rosengart, MD, MPH and Todd W. Costantini, MD	Ballroom AE
	O27. Paucity of Bacteria Implicated in Pathogenesis of Experimental Necrotizing Enterocolitis. Joanna Lim (Resident), presenting. Children's Hospital Los Angeles. Discussant: Michael J. Morowitz, MD
	O28. Pre-B Cell Colony Enhancing Factor (PBEF)/Nampt Phosphorylation by PI3 Kinase is Indispensable for the Inhibition of Neutrophil (PMN) Apoptosis in Patients with Sepsis. Song Jia (New Member), presenting. Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto. Discussant: John Mazuski, MD, PhD
	O29. Acute Appendicitis in Children is Associated with an Abundance of Bacteria from the Genus Fusobacterium. Matthew Rogers (New Member), presenting. Children's Hospital of Pittsburgh. Discussant: Jose J. Diaz, MD
	O30. Effect of Remote Ischemic Preconditioning on LPS-Induced Pulmonary Inflammation In Mice. So Jung Choi (New Member), presenting. University of Toronto. Discussant: Brian Eliceiri, PhD
	O31. Latent Cytomegalovirus Infection Predisposes Immune Competent Hosts to Pro-Inflammatory Pulmonary Immune Responses. Varun Dwivedi, presenting. The Ohio State University. Discussant: Ori Rotstein, MD
	O32. Defining The Mitochondrial DAMP Repertoire: Formyl Peptides are Not all Created Equal! Carl Hauser, presenting. Center for Vascular Biology Research, Harvard Medical School, BI Deaconess Medical Center. Discussant: Gary C. An, MD
17:00-18:00	Annual Business Meeting(Members only)	Ballroom AE
18:00	Free Evening

Saturday, April 18, 2015
07:00-08:00	Executive Council Meeting (By invitation)	Georgian
07:00-08:00	Breakfast	Garden Lawn
08:00-09:00	UPDATE SYMPOSIUM II What to do with the Darned Sub-specialists: Common Practices in Surgical Infections Moderator: Jeffrey Claridge, MD	Ballroom BCD
	Topic 1: Thoracic Surgery - Daniel Raymond Topic 2: Orthopedic Surgery - Antonia Chen
09:00-10:00	UPDATE SYMPOSIUM III PRO-CON DEBATES Moderator: John Mazuski, MD, PhD Patricia Byers vs. Michael Morowitz br />DEBATE: Fever-Suppress or Let it Ride? Carl Schulman vs. Kaysie Banton	Ballroom BCD
10:00-10:15	FELLOWSHIP AWARD RECIPIENT PRESENTATIONS Moderators: Philip S. Barie, MD, MBA and Kevin P. Mollen, MD SIS Foundation Basic or Translational Research Training Fellowship-2014 Anthony J. Lewis, MD. University of Pittsburgh SIS Foundation Clinical Research Training Fellowship-2014 Elinore J. Kaufman, MD. Weill Medical College of Cornell University SIS Foundation Junior Faculty Fellowship-2014-2015 Heather L. Evans, MD, MS. University of Washington	Ballroom BCD
10:15-10:30	BREAK-Visit the Exhibits
10:30-12:00	PARALLEL SESSION V Clinical Research (Papers 33-38) Moderators: Mary R. Kwaan, MD, MPH and David P. Blake, MD, MPH	Ballroom BCD
	O33. Does Circadian Rhythm Affect the Risk for Post-Operative Infectious Complications? Christopher Guidry (Resident), presenting. University of Virginia. Discussant: Christine S. Cocanour, MD
	O34. WITHDRAWN
	O35. Obesity Paradox in Patients with Soft Tissue Infections Nationwide. Elissa Lin, presenting. Brigham and Women's Hospital. Discussant: David P. Blake, MD, MPH
	O36. Developing an SSI Risk Score Incorporating Daily Objective Wound Assessments using Machine Learning. Heather L. Evans, presenting. University of Washington. Discussant: Donald E. Fry, MD
	O37. Component Separation versus Bridged Repair for Large Ventral Hernias: A Multi-Institutional Risk-Adjusted Comparison. Julie Holihan (Resident), presenting. University of Texas Health Science Center at Houston. Discussant: Kamal M. F. Itani, MD
	O38. Clinical Diagnosis of Infection in SICU: You are Not as Good as You Think! Madhu Subramanian (New Member), presenting. University of Texas, Southwestern. Discussant: Patrick J O'Neill, PhD, MD
10:30-12:00	PARALLEL SESSION VI Basic Science (Papers 39-43) Moderators: Gary C. An, MD and Rachel Khadaroo, MD, PhD	Ballroom AE
	O39. Characterization of the Murine Septic Response Using Wireless Telemetry Technology. Anthony Lewis (Resident), presenting. University of Pittsburgh. Discussant: Tina S. Mele, MD
	O40. Lactobacillus Probiotic Species Strengthen Intestinal Barrier Function and Tight Junction Integrity. Brian Blackwood (Resident), presenting. Northwestern University Feinberg School of Medicine. Discussant: John Marshall, MD
	O41. Mesenchymal Stem Cells Reverse Anemia and Bone Marrow Dysfunction Following Trauma, Hemorrhagic Shock, and Chronic Stress. Amy Gore (Resident), presenting. Rutgers-New Jersey Medical School. Discussant: Todd W. Costantini, MD
	O42. Remote Ischemic Preconditioning Plasma Prevents Neutrophil Infiltration by Increased Anti-oxidative Capacity in the Zebrafish. Chung Ho Leung, presenting. University of Toronto. Discussant: Brian Zuckerbraun, MD
	O43. Pseudomonas aeruginosa Infection Augments Burn-Induced Hepatic ER Stress. Mile Stanojcic (Resident), presenting. Sunnybrook Research Institute, University of Toronto, Toronto, Canada. Discussant: Steven E. Wolf, MD
12:00-13:15	LUNCHEON SYMPOSIUM (Industry-sponsored; not part of scientific program)	Garden Lawn
13:30-15:00	PARALLEL SESSION VII: The Surgical Infection Society-Supreme Court (Papers 44-48) Moderators: Pamela A. Lipsett, MD, MHE, John C. Alverdy, MD, John C. Marshall, MD, Robert G. Sawyer, MD, and William G. Cheadle, MD	Ballroom BCD
	O44. Computed Tomography Versus Ultrasound for the Diagnosis of Acute Cholecystitis. D. Dante Yeh, presenting. Harvard Medical School, Massachusetts General Hospital.
	O45. Comparison of Screening Tools' Ability to Detect Sepsis Accurately. Richard Wawrose, presenting. University of Texas Health Science Center at Houston.
	O46. Pulmonary Microbiome and Cytokine Analysis of Bronchoalveloar Lavage in Mechanically Ventilated Trauma Patients? Ryan M. Huebinger, presenting. University of Texas Southwestern.
	O47. The Transition from a Rural to Urban Environment in Africa Alters the Expression of Genes Involved in Cholesterol Metabolism: Potential Implications for Susceptibility to Infectious Diseases. Radhames Lizardo, presenting. University of California, San Diego.
	O48. Impact and Progression of Organ Dysfunction in Patients with Necrotizing Soft Tissue Infections; A Multicenter Study. Eileen M. Bulger, presenting. University of Washington.
16:00-17:20	POSTER SESSION (Posters 1- 52) Basic and Clinical Studies in Surgical Infection Moderators: Group 1: Cell Biology I (P1-P6) Michael Cripps, MD and Catherine J. Hunter, MD Group 2: Cell Biology II (P7-P11) Kevin P. Mollen, MD and Celeste C. Finnerty, PhD Group 3: Outcomes I (P12-P17) Patrick J. O’Neill, PhD, MD and Michael K. Liang, MD Group 4: Outcomes II (P18-P23) Soumitra R. Eachempati, MD and Charles A. Adams Jr., MD Group 5: Pathogens I (P24-P29) Jeffrey W. Shupp, MD and Barbara Trautner, MD, PhD Group 6: Pathogens II (P30-P35) Howard Belzberg, MD and Philip Chang, MD Group 7: Wounds and Incisions I (P36-P40) Christine S. Cocanour, MD and Jose J. Diaz, MD Group 8: Wounds and Incisions II (P41-P45) Weidun Alan Guo, MD and Kamal M. F. Itani, MD	Ballroom Foyer
19:00-19:45	New Member Reception	Ballroom Foyer
19:45-22:00	Awards Banquet	Ballroom
22:00	ADJOURNMENT

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40th Annual Meeting, Four Seasons Hotel Denver

Prevention and Education

Full Program

Wednesday, April 15, 2015

Thursday, April 16, 2015

Friday, April 17, 2015

Saturday, April 18, 2015

Thank you