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Purpose:
The Surgical Infection Society (SIS) Multicenter Study Initiative is established to facilitate the creation and execution of multicenter studies across the membership of the SIS. Approved studiesa re considered endorsed by the Surgical Infection Society.

The purpose of this initiative is to encourage collaborative multicenter investigation. In this capacity, the SIS aims to facilitate these collaborative efforts across centers. Ideally, these studies are investigator-initiated but do not require external funding. No financial resources will be provided on the part of the SIS solely due to participation in this initiative.

Requirements:

• Each submission must have an SIS mentor.
• Non-members are welcome to apply but will be required to join the SIS if selected.
• Residents and Fellows in training may apply but must have a faculty mentor as the Primary Investigator at the primary site that will be responsible for ensuring the project is completed.
• Primary Investigator must be an SIS member (or join the SIS if application is accepted).
• The topic must be deemed within the purview of the Surgical Infection Society. Special consideration will be given to those projects that directly address the stated research goals of the SIS. (PMID: 34357820) https://pubmed.ncbi.nlm.nih.gov/34357820/
• Investigational Review Board (IRB) approval is encouraged but not required for protocol submission.
• In the interest of data transparency, researchers will provide other SIS members with reasonable access to de-identified data when requested beginning one year after publication. https://cos.io/our-services/top-guidelines/

SIS MCT application form is available on the SIS website. Please send completed applications to SISadmin@SISNA.org.

Study protocols will be evaluated and reviewed by the SIS Scientific Studies Committee and two protocols will be chosen for participation.

Approved studies will be given dedicated time at the following Annual SIS meeting to formally outline their research goals and seek participants from within the SIS membership. The SIS Scientific Studies Committee will provide additional help identifying potential site participants and advertisement within the membership as needed (mass email to membership, etc.). Approved studies are strongly encouraged to use the free online REDCap database management and collection system (https://projectredcap.org).

Completed studies will discuss their findings at the Annual SIS meeting. Those studies that reach publication will include the heading "SIS Multicenter Study" in the title or subtitle. Manuscripts will be published in Surgical Infections.

Benefits of Participation:

• Access to hundreds of experts in surgical infections both nationally and internationally.
• Dedicated time to present research topic at SIS meeting.
• Assistance with advertising project to SIS membership via email and social media.

Timeline:

• Deadline for submission: TBA
• Decision by Scientific Studies Committee: February 15, 2022
• Presentation at SIS meeting: April 11-14, 2023

The Primary and Co-Primary Investigators (PI's) for the overall study will be the first two authors of the primary manuscript.  The PI and Co-PI for each contributing center will be listed in descending order from the center with the most enrolled patients to the center with the least. Only two authors will be considered from each contributing center. Surgical Infections allows a maximum of 35 authors to be listed.  Any additional authors will be listed at the conclusion of the manuscript as members of the "SIS Study Group".

Critical support personnel, including statisticians and other non-PI or Co-PI research personnel may be recognized in a brief Acknowledgement Section.

For all subsequent and secondary manuscripts constructed using data from the primary study, authorship will be adjusted according to the contribution to that particular manuscript.  The original PI and the Scientific Studies committee chair must approve all subsequent analyses.  Additionally, all original contributing authors must be given a reasonable opportunity to contribute to the manuscript.